EDUCATION:

• 1987   B.S.,    Tsinghua University
• 1989   M.S.,   Tsinghua University
• 1999   Ph.D.,  Georgia Institute of Technology

RESEARCH EXPERIENCES:

• 1989-1994   Research Associate, Institute of Photographic Chemistry, Chinese Academy of Sciences
• 1994-1995   Visiting Scholar, University of California at Los Angeles and Georgia Institute of Technology
• 1999-2001   Postdoc., Georgia Institute of Technology
• 2001-2006   Postdoc., University of Pennsylvania
• 2006-           Professor, Institute of Chemistry, Chinese Academy of Sciences

CURRENT RESEARCH INTERESTS:

In our quantum multidimensional infrared (QMDIR) spectroscopy laboratory, we are constructing a femtosecond broadband two-dimensional infrared (2D IR) spectroscopic technique that is relevant to condensed-phase chemistry, physics, and biology. 2D IR spectroscopy can provide a chemical-bond level description of a molecular complex with ultrafast time resolution. Recent 2D IR experimental and theoretical studies have shown many anharmonic vibrational parameters are sensitive to molecular structure and dynamics. With the broadband technique, pairs of remote chemical bonds can be targeted and studied simultaneously, allowing one to describe the time-dependence of structural changes of the molecular complex in detail. It is expected to gain new insights into fundamental issues of ultrafast structural dynamics, chemical reactions, and protein folding and misfolding events. Our long-term goal is to establish multidimensional spectroscopic technique to other wavelength ranges, such as near IR, visible, and X-rays.

Our research also takes advantage of modern quantum chemical computations and (ab initio or classical) molecular dynamics simulations, which allow us to predict anharmonic vibrational parameters, to understand and to simulate broadband 2D IR spectra (Figure 1), as well as to follow the structural evolution of a condensed-phase molecular complex on the ultrafast time scale.

                Figure 1

PUBLICATIONS:

• Guixiu Wang, Xiaoyan Ma, and Jianping Wang, "Anharmonic vibrational signatures of DNA bases and Watson-Crick base pairs", Chinese J. Chem. Phys. 2009, 22, 563-570.
• Kaicong Cai, Chen Han, and Jianping Wang, "Molecular mechanics force field-based map for peptide amide-I mode in solution and its application to alanine di- and tripeptides", Phys. Chem. Chem. Phys. 2009, 11, 9149-9159.
• Jianping Wang, Kaicong Cai, and Xiaoyan Ma, "Ultrafast structural dynamics of biomolecules examined by multiple-mode 2D IR spectroscopy: anharmonically coupled motions are in harmony", ChemPhysChem 2009, 10, 2242-2250.
• Wenbing Hu, Qun Luo, Xiaoyan Ma, Kui Wu, Jianan Liu, Yi Chen, Shaoxiang Xiong, Jianping Wang, Peter J. Sadler, and Fuyi Wang, "Arene control over thiolate to sulfinate oxidation in albumin by organometallic ruthenium anticancer complexes", Chem. Eur. J. 2009, 15, 6586-6594.
• Jianping Wang, "Assessment of the amide-I local modes in γ- and β-turns of peptides", Phys. Chem. Chem. Phys. 2009, 11, 5310-5322.
• Xiaoyan Ma and Jianping Wang, "Differentiating subtle variation of weak intramolecular hydrogen bond in vicinal diols by linear infrared spectroscopy", J. Phys. Chem. A 2009, 113, 6070-6076.
• Hui Zhou, Xiaoyan Ma, Jianping Wang, and Lilu Zhang, "Pyrene acetylide nucleotides in GNA: probing duplex formation and sensing of copper(II) ions", Org. Biomol. Chem. 2009, 7, 2297-2302.
• Jianping Wang and Mostafa A. El-Sayed, "Rapid thermal tuning of chromophore structure in membrane protein", J. Phys. Chem. B (Letter) 2009, 113, 4184-4186.
• Kaicong Cai and Jianping Wang, "Multiple anharmonic vibrational probes of sugar structure and dynamics", J. Phys. Chem. B 2009, 113, 1681-1692.
• Jianping Wang, "Structurally sensitive anharmonic Cα-D stretch vibration in deuterated peptides", J. Phys. Chem. B (Letter) 2009, 113, 1813-1816.
• Jianping Wang, "Conformational dependence of anharmonic NH stretch vibration in peptides", Chem. Phys. Lett. 2009, 467, 375-380.
• Kaicong Cai and Jianping Wang, "Molecular dynamical structures of glycolaldehyde", Acta Phys. Chim. Sin., 2009, 25, 677-683. (In Chinese)
• Jianping Wang, "Conformational dependence of anharmonic vibrations in peptides: amide-I modes in model dipeptide", J. Phys. Chem. B 2008, 112, 4790-4800.
• Wenwei Zhao, Lu Pan, Wensheng Bian, and Jianping Wang, "Influence of solvent polarity and hydrogen bonding on the electronic transition of Coumarin 120: a TDDFT study", ChemPhysChem 2008, 9, 1593-1602.
• Jianping Wang, Wei Zhuang, Shaul Mukamel, and Robin M. Hochstrasser, "Two-dimensional infrared spectroscopy as a probe of the solvent electrostatic field for a twelve residue peptide", J. Phys. Chem. B 2008, 112, 5930-5937. (Attila Szabo Festschrift)
• Jianping Wang, Kaicong Cai, Xiaoyan Ma, and Guixiu Wang, "Anharmonic vibration modes can be used as inherent biomolecular dynamical structure probes", Spectrosc. Spect. Anal. 2008, 28, 173-174. (In Chinese)
• Xiaoyan Ma and Jianping Wang, "Two-dimensional infrared spectroscopic parameters of diols", Spectrosc. Spect. Anal. 2008, 28, 175-176. (In Chinese)
• Kaicong Cai and Jianping Wang, "Anharmonic vibration of glycolaldehyde and its solvation effect", Spectrosc. Spect. Anal. 2008, 28, 177-178. (In Chinese)
• Guixiu Wang and Jianping Wang, "Anharmonic Interactions of Watson-Crick Base Pairs", Spectrosc. Spect. Anal. 2008, 28, 471-472. (In Chinese)
• Jianping Wang, "Ab initio-based all-mode two-dimensional infrared spectroscopy of a sugar molecule", J. Phys. Chem. B 2007, 111, 9193-9196. (Letter)
• Jianping Wang, "Femtosecond laser two-dimensional infrared spectroscopy", Chin. Sci. Bull. 2007, 52, 1221-1231. (review)
• Jianping Wang, "Anharmonic C-H and C=O interactions in peptide and sugar", Chinese J. Chem. Phys. 2007, 20, 475-482.
• Jianping Wang, "Two-dimensional infrared spectroscopy of a model peptide homodimer", Chinese J. Chem. Phys. 2007, 20, 509-517.
• Jianping Wang and Robin M. Hochstrasser, "Anharmonicity of amide modes", J. Phys. Chem. B 2006, 110, 3798-3807. (Michael L. Klein Festschrift, published on web on 08/23/2005)
• Jianping Wang, Jianxin Chen, and Robin M. Hochstrasser, "Local structure of ß-hairpin isotopomers by FTIR, 2D IR and ab initio theory", J. Phys. Chem. B 2006, 110, 7545-7555.
• Jianping Wang and Robin M. Hochstrasser, "Characteristics of the two-dimensional infrared spectroscopy of helices from approximate simulations and analytic models", Chem. Phys. 2004, 297, 195-219.
• Cynthia Paul, Jianping Wang, William C. Wimley, Robin M. Hochstrasser, and Paul H. Axelsen, "Vibrational coupling, isotopic editing, and ß-sheet structure in a membrane bound polypeptide", J. Am. Chem. Soc. 2004, 126, 5843-5850.
• Igor V. Rubtsov, Jianping Wang, and Robin M. Hochstrasser, "Dual-frequency 2D-IR spectroscopy heterodyned photon echo of the peptide bond", Proc. Natl. Acad. Sci. USA 2003, 100, 5601-5606.
• Jianping Wang, Stephan, Link, Colin D. Heyes, and Mostafa A. El-Sayed, "Comparison of the dynamics of the primary events of bacteriorhodopsin in its trimeric and monomeric states", Biophys. J. 2002, 83, 1557-1566.
• Jianping Wang, Daoji Gan, L. Andrew Lyon, and Mostafa A. El-Sayed, "Temperature-jump investigations of the kinetics of hydrogel nanoparticle volume phase transitions", J. Am. Chem. Soc. 2001, 123, 11284-11289.
• Jianping Wang and Mostafa A. El-Sayed, "Temperature-jump induced secondary structural change of the membrane protein bacteriorhodopsin in the pre-melting temperature region: a nanosecond time-resolved FTIR study", Biophys. J. 1999, 76, 2777-2783.
• Jianping Wang, Seoungkyo Yoo, Li Song, and Mostafa A. El-Sayed, "Molecular mechanism of the differential photoelectric response of bacteriorhodopsin", J. Phys. Chem. B 1997, 101, 3420-3423.
• Jianping Wang, Jinru Li, Peide Tao, Xingchang Li, and Long Jiang, "Photoelectrochemical properties of bacteriorhodopsin Langmuir-Blodgett films on ITO conductive electrode", Science in China Ser. B 1994, 37, 1192-1197.