王建平研究员

::王建平研究员::

办公室：  化学所2号楼212室
电话：      +86-10-62656806
传真：      +86-10-62563167
电子信箱：jwang@iccas.ac.cn
组内网页：http://qmdir.iccas.ac.cn

简历：

1982－1987 清华大学化学系,理学学士
1987－1989 清华大学化学系,理学硕士
1989－1994 中国科学院感光化学研究所,助研
1994－1995 美国加州大学洛杉矶分校和佐治亚理工学院,访问学者
1995－1999 美国佐治亚理工学院化学与生物化学系,理学博士
1999－2001 美国佐治亚理工学院,博士后
2001－2006 美国宾夕法尼亚大学,博士后
2006－现在中国科学院化学所“百人计划”,分子反应动力学国家重点实验室,研究员,博士生导师

|研究领域和兴趣|

我们量子多维红外 (QMDIR) 光谱实验室正在建设与凝聚相化学, 物理, 和生物学等领域密切相关的飞秒宽带两维红外 (2D IR) 光谱技术。2D IR 光谱具有以超快时间分辨率在化学键水平上测定分子结构的能力。近来的 2D IR 实验和理论研究表明许多非谐性振动参数对分子结构和动力学都很敏感。利用宽带 2D IR 光谱技术, 我们可以研究成对化学基团之间的相对方位及距离, 用于跟踪凝聚相中分子的结构变迁。所得结果将有助于我们认识分子超快结构动力学, 化学反应, 以及蛋白质折叠和聚集等过程。远期目标是在其它波段建立多维光谱技术, 如近红外, 可见, X 射线。

2d ir

图1. 氘代乙醇醛宽带 2D IR 模拟局部

我们的研究还包括利用现代量子化学计算和 (从头算或经典力学) 分子动力学模拟方法来预测非谐性振动参数, 模拟宽带两维红外光谱 (如图1), 从而在超快时间尺度上描述凝聚相复杂分子的结构变化。

|主要学术论文|

Guixiu Wang, Xiaoyan Ma, and Jianping Wang, "Anharmonic vibrational signatures of DNA bases and Watson-Crick base pairs", Chinese J. Chem. Phys. 2009, 22, 563-570.
Kaicong Cai, Chen Han, and Jianping Wang, "Molecular mechanics force field-based map for peptide amide-I mode in solution and its application to alanine di- and tripeptides", Phys.Chem. Chem. Phys. 2009, 11, 9149-9159.
Jianping Wang, Kaicong Cai, and Xiaoyan Ma, "Ultrafast structural dynamics of biomolecules examined by multiple-mode 2D IR spectroscopy: anharmonically coupled motions are in harmony", ChemPhysChem 2009, 10, 2242-2250.
Wenbing Hu, Qun Luo, Xiaoyan Ma, Kui Wu, Jianan Liu, Yi Chen, Shaoxiang Xiong, Jianping Wang, Peter J. Sadler, and Fuyi Wang, "Arene control over thiolate to sulfinate oxidation in albumin by organometallic ruthenium anticancer complexes", Chem. Eur. J. 2009, 15, 6586-6594.
Jianping Wang, "Assessment of the amide-I local modes in γ- and β-turns of peptides", Phys. Chem. Chem. Phys. 2009, 11, 5310-5322.
Xiaoyan Ma and Jianping Wang, "Differentiating subtle variation of weak intramolecular hydrogen bond in vicinal diols by linear infrared spectroscopy", J. Phys. Chem. A 2009, 113, 6070-6076.
Hui Zhou, Xiaoyan Ma, Jianping Wang, and Lilu Zhang, "Pyrene acetylide nucleotides in GNA: probing duplex formation and sensing of copper(II) ions", Org. Biomol. Chem. 2009, 7, 2297-2302.
Jianping Wang and Mostafa A. El-Sayed, "Rapid thermal tuning of chromophore structure in membrane protein", J. Phys. Chem. B (Letter) 2009, 113, 4184-4186.
Kaicong Cai and Jianping Wang, "Multiple anharmonic vibrational probes of sugar structure and dynamics", J. Phys. Chem. B 2009, 113, 1681-1692.
Jianping Wang, "Structurally sensitive anharmonic Cα-D stretch vibration in deuterated peptides", J. Phys. Chem. B (Letter) 2009, 113, 1813-1816.
Jianping Wang, "Conformational dependence of anharmonic NH stretch vibration in peptides", Chem. Phys. Lett. 2009, 467, 375-380.
Kaicong Cai and Jianping Wang, "Molecular dynamical structures of glycolaldehyde", Acta Phys. Chim. Sin., 2009, 25, 677-683. (In Chinese)
Jianping Wang, "Conformational dependence of anharmonic vibrations in peptides: amide-I modes in model dipeptide", J. Phys. Chem. B 2008, 112, 4790-4800.
Wenwei Zhao, Lu Pan, Wensheng Bian, and Jianping Wang, "Influence of solvent polarity and hydrogen bonding on the electronic transition of Coumarin 120: a TDDFT study", ChemPhysChem 2008, 9, 1593-1602.
Jianping Wang, Wei Zhuang, Shaul Mukamel, and Robin M. Hochstrasser, "Two-dimensional infrared spectroscopy as a probe of the solvent electrostatic field for a twelve residue peptide", J. Phys. Chem. B 2008, 112, 5930-5937. (Attila Szabo Festschrift)
Jianping Wang, Kaicong Cai, Xiaoyan Ma, and Guixiu Wang, "Anharmonic vibration modes can be used as inherent biomolecular dynamical structure probes", Spectrosc. Spect. Anal. 2008, 28, 173-174. (In Chinese)
Xiaoyan Ma and Jianping Wang, "Two-dimensional infrared spectroscopic parameters of diols", Spectrosc. Spect. Anal. 2008, 28, 175-176. (In Chinese)
Kaicong Cai and Jianping Wang, "Anharmonic vibration of glycolaldehyde and its solvation effect", Spectrosc. Spect. Anal. 2008, 28, 177-178. (In Chinese)
Guixiu Wang and Jianping Wang, "Anharmonic Interactions of Watson-Crick Base Pairs", Spectrosc. Spect. Anal. 2008, 28, 471-472. (In Chinese)
Jianping Wang, "Ab initio-based all-mode two-dimensional infrared spectroscopy of a sugar molecule", J. Phys. Chem. B 2007, 111, 9193-9196. (Letter)
Jianping Wang, "Femtosecond laser two-dimensional infrared spectroscopy", Chin. Sci. Bull. 2007, 52, 1221-1231. (review)
Jianping Wang, "Anharmonic C-H and C=O interactions in peptide and sugar", Chinese J. Chem. Phys. 2007, 20, 475-482.
Jianping Wang, "Two-dimensional infrared spectroscopy of a model peptide homodimer", Chinese J. Chem. Phys. 2007, 20, 509-517.
Jianping Wang and Robin M. Hochstrasser, "Anharmonicity of amide modes", J. Phys. Chem. B 2006, 110, 3798-3807. (Michael L. Klein Festschrift, published on web on 08/23/2005)
Jianping Wang, Jianxin Chen, and Robin M. Hochstrasser, "Local structure of ß-hairpin isotopomers by FTIR, 2D IR and ab initio theory", J. Phys. Chem. B 2006, 110, 7545-7555.
Jianping Wang and Robin M. Hochstrasser, "Characteristics of the two-dimensional infrared spectroscopy of helices from approximate simulations and analytic models", Chem. Phys. 2004, 297, 195-219.
Cynthia Paul, Jianping Wang, William C. Wimley, Robin M. Hochstrasser, and Paul H. Axelsen, "Vibrational coupling, isotopic editing, and ß-sheet structure in a membrane bound polypeptide", J. Am. Chem. Soc. 2004, 126, 5843-5850.
Igor V. Rubtsov, Jianping Wang, and Robin M. Hochstrasser, "Dual-frequency 2D-IR spectroscopy heterodyned photon echo of the peptide bond", Proc. Natl. Acad. Sci. USA 2003, 100, 5601-5606.
Jianping Wang, Stephan, Link, Colin D. Heyes, and Mostafa A. El-Sayed, "Comparison of the dynamics of the primary events of bacteriorhodopsin in its trimeric and monomeric states", Biophys. J. 2002, 83, 1557-1566.
Jianping Wang, Daoji Gan, L. Andrew Lyon, and Mostafa A. El-Sayed, "Temperature-jump investigations of the kinetics of hydrogel nanoparticle volume phase transitions", J. Am. Chem. Soc. 2001, 123, 11284-11289.
Jianping Wang and Mostafa A. El-Sayed, "Temperature-jump induced secondary structural change of the membrane protein bacteriorhodopsin in the pre-melting temperature region: a nanosecond time-resolved FTIR study", Biophys. J. 1999, 76, 2777-2783.
Jianping Wang, Seoungkyo Yoo, Li Song, and Mostafa A. El-Sayed, "Molecular mechanism of the differential photoelectric response of bacteriorhodopsin", J. Phys. Chem. B 1997, 101, 3420-3423.
Jianping Wang, Jinru Li, Peide Tao, Xingchang Li, and Long Jiang, "Photoelectrochemical properties of bacteriorhodopsin Langmuir-Blodgett films on ITO conductive electrode", Science in China Ser. B 1994, 37, 1192-1197.

|主要学术会议与报告|

Jianping Wang, "生物分子超快结构动力学的多模式 2D IR 表征", talk. XIth National Chemical Dynamics Symposium, August 13-17 (Yichang-Chongqing, China) I10, 2009.
Jianping Wang, "非谐性振动模可作为生物分子内在的动态结构探针", talk. 15th National Conference on Molecular Spectroscopy, October 17-20 (Beijing, China) 2008.
Jianping Wang, "Broadband two-dimensional infrared spectra of peptides based on ab initio computations", talk. Colloquium Spectroscopium Internationale XXXV, September 23-27 (Xiamen, China) 302, 2007.
Jianping Wang, "Vibrational quantum coherence in a molecule by broadband two-dimensional infrared spectroscopy", poster. Gordon Research Conference, August 12-17 (Newport, RI) 25, 2007.
Jianping Wang, "飞秒二维红外光谱与分子结构动力学", poster. Xth National Chemical Dynamics Symposium, September 21-24 (Dalian, China) C03, 2007.
Jianping Wang, "Vibrational coherences and intramolecular interactions probed by two-dimensional infrared spectroscopy", poster. Xth National Chemical Dynamics Symposium, September 21-24 (Dalian, China) C04, 2007.
Jianping Wang, Jianxin Chen, and Robin M. Hochstrasser, "Probing the beta-hairpin local structure by FTIR, 2D IR and ab initio calculations", talk. Am. Phys. Soc. March 13-17 (Baltimore, MD) A13.00003, 2006.
Jianping Wang, Chong Fang, Yungsam Kim, Paul H. Axelsen, and Robin M. Hochstrasser, "Vibrational couplings in peptide oligomers examined by ab initio calculations and multidimensional infrared spectral measurements", poster. The 228th American Chemical Society National Meeting, Philadelphia, PA, USA, August 22-26, 2004.
Jianping Wang, and Mostafa A. El-Sayed, "Conformation transition from αII to αI and proton pumping in bacteriorhodopsin photocycle", poster. The 220th American Chemical Society National Meeting, Washington, DC, USA. August 20-24, 2000.
Jianping Wang and Mostafa A. El-Sayed, "The effect of the protein conformation change from αII to αI on bacteriorhodopsin photocycle", poster. The 44th Biophysics Society National Meeting, New Orleans, LA, USA. March 20-27, 2000.
Jianping Wang, Seoungkyo Yoo, Li Song, and Mostafa A. El-Sayed, "On the molecular mechanism of the differential photocurrent response of bacteriorhodopsin", poster. The 212th American Chemical Society National Meeting, Orlando, Florida, USA. August 25-29, 1996.
Jianping Wang, Li Song, and Mostafa A. El-Sayed, "A comparison of the photoelectric current responses resulting from the proton pumping processes of bacteriorhodopsin under pulsed and CW laser excitations", poster. American Society for Photobiology, Atlanta, Georgia, USA. June 15-20, 1996.
Jianping Wang, Li Song, and Mostafa A. El-Sayed, "Mechanism of the differential photoelectric response in bacteriorhodopsin-based photocells", poster. The 210th American Chemical Society National Meeting, Chicago, Illinois, USA. August 20-24, 1995.

招聘：

            飞秒多维红外光谱实验室研究团队正在招聘以下人员：

            专业相符的工作人员 (副研, 助研) 1～2 人；博士后 2 人。
            要求背景：凝聚相超快结构动力学相关专业, 具有飞秒激光光谱 (如可见、红外泵浦探测等) 和非线性光学等相关实验背景。


            符合条件者请把简历, 相关学术文章和 2～3 封推荐信发给中国科学院化学研究所分子反应动力学 王建平教授
            联系方式： jwang@iccas.ac.cn
            联系电话： +86-10-62656806

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